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fMRI Evaluation of Auricular Acupuncture Targets: An Exploratory Clinical Study | Clinical Trials | Clareo Health

RECRUITINGNA

fMRI Evaluation of Auricular Acupuncture Targets: An Exploratory Clinical Study

An Exploratory Clinical Study on fMRI-Based Evaluation of Intervention Targets for Auricular Acupuncture Therapy

NCT07332962•Jiangsu Taizhou People's Hospital

Summary

This study employs resting-state functional magnetic resonance imaging (rs-fMRI) to examine whether auricular press needles acupuncture modulates functional connectivity between the insula and medial prefrontal cortex (MPFC), in a manner comparable to transcranial vagus nerve stimulation (taVNS), and to assess its association with interoceptive improvement. By establishing a neurophysiological baseline for auricular vagus nerve stimulation (aVNS) in the healthy brain, the research aims to clarify its regulatory mechanisms in cognition and emotion. The findings provide a key theoretical and evaluative framework for translating aVNS into clinical applications for insomnia and depression.

Eligibility

Age

18 - 30 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Age 18-30 years;
•2. Basically normal diet and sleep;
•3. No history of mental illness;
•4. No MRI contraindications (e.g., metal implants or pacemakers) or claustrophobia；
•5. Willing to participate in this study and sign the informed consent form.

Exclusion Criteria

•1. Presence of auricular skin lesions or allergy to adhesive ear patches;
•2. Currently receiving regular acupuncture treatment;
•3. History of bleeding disorders or anticoagulant use (increased bleeding risk);
•4. Previous history of syncope during acupuncture.

Locations (1)

Taizhou People's Hospital affiliated to Nanjing Medical University

Taizhou, Jiangsu, China

Key Dates

Start Date

December 20, 2025

Primary Completion Date

January 15, 2026

Completion Date

January 30, 2026

Last Updated

January 12, 2026

Enrollment

ESTIMATED participants

Conditions

Healthy Participants

Interventions

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Sham Auricular Acupuncture as a Control Intervention for Brain fMRI Studies in Healthy Volunteers

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 12, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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fMRI Evaluation of Auricular Acupuncture Targets: An Exploratory Clinical Study

Inclusion Criteria

Exclusion Criteria

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