Human Laboratory Study of Apremilast for Alcohol Use Disorder

Inclusion Criteria

• •1. Be at least 21 years of age.
• •2. Have a current (past 12 months) DSM-5 diagnosis of AUD (4 or more symptoms) assessed using the MINI neuropsychiatric interview version 7.0.2 (at least moderate severity).
• •3. Have a BAC by breathalyzer equal to 0.000 when s/he signed the informed consent document (either just prior to or immediately after signing consent).
• •4. Be seeking treatment for problems with alcohol and express a goal of abstinence or a reduction in drinking.
• •5. Be able to verbalize an understanding of the consent form, able to provide written informed consent, verbalize willingness to complete study procedures, able to understand written and oral instructions in English and able to complete the questionnaires required by the protocol.
• •6. Agree (if the participant is female and of childbearing potential) to use at least one of the following methods of birth control, unless she is surgically sterile, partner is surgically sterile or she is postmenopausal:
• •* oral contraceptives,
• •* contraceptive sponge,
• •* patch,
• •* double barrier (diaphragm/spermicidal or condom/spermicidal),
• +22 more criteria