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COMPLETEDNA

Clinical Efficacy of Using Bioactive Desensitizer Gel

Clinical Efficacy of Using Bioactive Desensitizer Gel Versus Sodium Fluoride Varnish on Cervical Dentin Hypersensitivity in Adult Patients: A 6m Randomized Clinical Trial

NCT07323693•Cairo University

View on ClinicalTrials.gov

Summary

To evaluate and compare the clinical effectiveness of a Bioactive Desensitizer Gel (which releases calcium and phosphate to form hydroxyapatite) versus a standard 5% Sodium Fluoride (NaF) Varnish in reducing cervical dentin hypersensitivity (CDH) in adult patients over a period of 6 months.

Eligibility

Age

18 - 30 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•• With ≥1 sensitive tooth and with exposed dentin in the upper or lower dental arches.
•* Grade IV gingival recession.
•* Schiff sensitivity score needed to be ≥2, indicating that application of a jet of air makes the patient respond and move or requests discontinuation of the stimuli application.

Exclusion Criteria

•• Domestic or in-office fluoride application and bleaching 6 months before beginning of treatment
•* Long-term use of anti-inflammatory, analgesic and psychotropic drugs.
•* Allergies to product ingredients
•* Eating disorders, systemic conditions that cause or predispose patients to develop dentin hypersensitivity (for example, gastroesophageal reflux disease, GERD)
•* Excessive dietary or environmental exposure to acids.
•* Orthodontic appliance treatment within the previous three months.
•* Periodontal surgery within the previous three months before the study

Locations (1)

Faculty of Dentistry

Cairo, Egypt

Key Dates

Start Date

November 20, 2024

Primary Completion Date

September 20, 2025

Completion Date

December 20, 2025

Last Updated

January 7, 2026

Enrollment

ACTUAL participants

Conditions

Dentin Desensitizing AgentsDentin Hypersensitivity, Non-carious Cervical LesionsDentin Hypersensitivity

Interventions

Treatment

PROCEDURE

Treatment

PROCEDURE

Hydroxyapatite-Based Home Treatment for Dentin Sensitivity in Celiac Patients

NCT07069127

Celiac DiseaseDentin Hypersensitivity+1 more

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COMPLETEDNA

Validation of a French Version of the DHEQ

NCT06466200

Dentin HypersensitivityQuality of Life

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 7, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Clinical Efficacy of Using Bioactive Desensitizer Gel

Inclusion Criteria

Exclusion Criteria

Hydroxyapatite-Based Home Treatment for Dentin Sensitivity in Celiac Patients

Validation of a French Version of the DHEQ

Diode Laser Plus CPP-ACPF vs CPP-ACPF Alone for Dentin Hypersensitivity

Combined Use of Potassium Nitrate Gel and Diode Laser for Dentin Hypersensitivity

Efficacy of Universal Bonding Agents as Desensitizers

Gluma Compared With Bonding Agent for Post-operative Sensitivity Following Composite Restorations