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Comparing Microneedling and Injectable Platelet Rich Fibrin to Hyaluronic Acid In Papilla Reconstruction | Clinical Trials | Clareo Health

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Comparing Microneedling and Injectable Platelet Rich Fibrin to Hyaluronic Acid In Papilla Reconstruction

Comparative Evaluation of Microneedling With Injectable PRF and Hyaluronic Acid for Papilla Reconstruction: A Randomized Clinical Trial

NCT07280507•King Abdulaziz University

View on ClinicalTrials.gov

Summary

This randomized split-mouth clinical trial aims to compare the clinical effectiveness of microneedling combined with injectable platelet-rich fibrin (i-PRF) versus hyaluronic acid (HA) gel injection in the reconstruction of Class I interdental papilla loss. The study hypothesizes that MN + i-PRF will yield greater papillary regeneration, offering a minimally invasive, biologically active alternative to traditional surgical approaches for soft-tissue esthetic rehabilitation.

Eligibility

Age

18 - 45 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Plaque index \<1
•Gingival index \<1
•Class I papillary loss (Nordland and Tarnow classification)
•Probing depth ≤4 mm at the test site
•Inter-proximal bone crest distance ≤7 mm from the contact point.

Exclusion Criteria

•Pregnancy
•Lactation
•Uncontrolled systemic diseases (e.g., diabetes)
•Anticoagulant therapy
•Recent radiotherapy
•Orthodontic treatment
•Midline diastema
•High frenum attachment
•Class II/III papillary loss.

Locations (1)

King AbdulAziz University

Jeddah, Saudi Arabia

Key Dates

Start Date

November 24, 2025

Primary Completion Date

March 1, 2026

Completion Date

September 30, 2026

Last Updated

December 12, 2025

Enrollment

ESTIMATED participants

Conditions

Papilla Reconstruction

Interventions

Injectable Platelet Rich Fibrin

BIOLOGICAL

Hyaluronic Acid (HA)

OTHER

Injectable Platelet-Rich Fibrin and Microneedling For Papillae Reconstruction In Esthetic Zone

NCT06021301

Injectable Platelet Rich Fibrin and Microneedling in Papilla ReconstructionInterdental Papillae Reconstruction

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 12, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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