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A Randomized, Double-Blind Study to Evaluate the Safety, Tolerability, and Immunogenicity of V118 Formulation E in Healthy Adults
Researchers are looking for new vaccines to prevent illnesses caused by a type of bacteria called Streptococcus pneumoniae. There are many different types of Streptococcus pneumoniae bacteria, called serotypes. Vaccines contain small parts of certain serotypes. These parts will not cause an infection but help the body create antibodies (proteins) to fight the bacteria. PREVNAR 20™ is a vaccine given to help to prevent disease from Streptococcus pneumoniae bacteria. Researchers designed a new vaccine, V118E, to help prevent disease from Streptococcus pneumoniae bacteria. The goal of this study is to learn how safe V118 formulation E is in Healthy Adults and how well people tolerate it.
Age
18 - 49 years
Sex
ALL
Healthy Volunteers
Yes
Velocity Clinical Research, Hallandale Beach ( Site 0003)
Hallandale, Florida, United States
QPS-MRA, LLC-Early Phase ( Site 0002)
South Miami, Florida, United States
Bio-Kinetic Clinical Applications, LLC dba QPS-MO ( Site 0004)
Springfield, Missouri, United States
University of Texas Medical Branch ( Site 0001)
Galveston, Texas, United States
Start Date
October 8, 2025
Primary Completion Date
November 12, 2027
Completion Date
November 12, 2027
Last Updated
February 27, 2026
126
ESTIMATED participants
V118E
BIOLOGICAL
PREVNAR 20™
BIOLOGICAL
Saline
BIOLOGICAL
Lead Sponsor
Merck Sharp & Dohme LLC
NCT07310264
NCT00090662
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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