Short Course Radiotherapy

Pilot Trial of Short Course Radiotherapy for Primary or Secondary CNS Malignancies

NCT07147179•Abramson Cancer Center at Penn Medicine

Summary

This is a single arm prospective pilot trial determining the safety of short-course radiation therapy in pediatric patients with incurable central nervous system malignancies.

Detailed Description

Participants will receive a shorter course of radiation therapy across 5 days (20 Gray in 5 fractions) in contrast to the standard treatment of two weeks or more of daily treatments (up to 3 Gray per day). This research study is being conducted to see if delivering a shorter course of radiation therapy is safe and helps quality of life so that it may reduce the required duration of palliative treatment.

Eligibility

Age

0 - 21 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Male or female, aged 21 years or below
•Lansky performance status \>= 40
•Has a diagnosis of an incurable malignancy that:
•* Originates outside the brain but is metastatic to 1 or more sites within the brain, or originates and recurs within the brain. For this diagnosis to be confirmed, there must be multidisciplinary review of up to date imaging at a pediatric tumor board with unanimous consensus of intracranial relapse or metastasis. If the consensus is not unanimous, short-interval repeat imaging with subsequent unanimous consensus would be required in order for this eligibility criteria to be met
•* Has at least 1 targetable intracranial lesion as seen on imaging
•* Has a multidisciplinary consensus recommendation for palliative intent radiation
•Consents to the study or has caregiver who is able to provide signed and dated informed consent. For subjects under the age of 18, a signed and dated assent form as able.
•Patients who had prior radiation in planned treatment area are also eligible to enter the trial
•Stated willingness to comply with all study procedures and availability for the duration of the study

Exclusion Criteria

•Radiotherapy for curative intent
•Serious uncontrolled systemic or psychiatric disorders that would interfere with participation in the protocol
•Being planned for proton radiation

Locations (1)

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Key Dates

Start Date

February 1, 2026

Primary Completion Date

March 1, 2027

Completion Date

March 1, 2027

Last Updated

January 22, 2026

Enrollment

ESTIMATED participants

Conditions

Central Nervous System Cancer

Interventions

Short Course Radiotherapy

RADIATION

Contacts

Kelly Clark

CONTACT

267-854-5332 Kelly.Clark3@pennmedicine.upenn.edu

Mind Over Matter for Black and African American Women: A Single Arm Trial Examining Feasibility and Acceptability of a Supportive Intervention

NCT06168825

CancerBreast Cancer+14 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 22, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions