De-escalation in Axillary Surgery for Early-stage Breast Cancer

Exclusion Criteria

• •Patients younger than 55 years of age and/or premenopausal, with cN1-3 status (confirmed cytologically or histologically), or with multiple suspicious lymph nodes on axillary ultrasound, regardless of cytological/histological confirmation.
• •Patients diagnosed with pure breast carcinoma in situ (DCIS) without focal invasion
• •Patients with tumour larger than 3 cm or with cT4 status, with de novo metastatic disease
• •Patients with a breast cancer of HER2+ or triple-negative immunophenotype
• •Patients who have received any type of neoadjuvant systemic therapy before surgery and those who have a previous personal history of invasive breast cancer
• •Patients with extensive multifocal or multicentric breast cancer, patients scheduled for mastectomy, partial breast irradiation or who refuse recommended adjuvant systemic oncological treatment
• •Patients who do not wish to participate in a clinical trial