Tonsillectomy and Immunosuppression in Caucasian Patients With High-risk IgA-nephropathy

Exclusion Criteria

• •1. Age \<18 or \>75 years;
• •2. eGFR ≤20 ml/min/1.73m2
• •3. Patients with mild renal lesions (M0, E0, S0, T0, C0), minor urinary findings, DP \<1.0 g
• •4. Contraindications to IST or TE
• •5. Patients with any co-existing kidney disease
• •6. Patients with secondary IgAN (Schoenlein-Henoch purpura, liver cirrhosis, etc.)
• •7. Patients with diabetes mellitus
• •8. Any clinically significant acute illness within 60 days prior to kidney biopsy (including infection, aseptic necrosis of any bone, patients with myocardial infarction or cerebrovascular stroke, other conditions that can be exacerbated by corticosteroids
• •9. Incomplete empiric IST administered prior to kidney biopsy
• •10. Pregnancy