5-AminoLevulinic Acid Aided Resection Margins in Sarcoma

Inclusion Criteria

• •1. Histological confirmation of any subtype of primary Grades 2 or 3 soft tissue sarcomas (STS), per biopsy evaluation by a pathologist, according to Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC).
• •2. Treatment decision includes planned surgical resection of STS.
• •3. Age ≥18 years at time of consent.
• •4. ECOG Performance Status 0 - 1.
• •5. Hematology and blood chemistry parameters defined by:
• •1. Leukocytes ≥ 3 × 10(9)/L
• •2. Absolute neutrophil count ≥ 1.5 × 10(9)/L
• •3. Platelets ≥ 100 × 109/L, transfusions may be used to raise platelets to ≥ 100 × 10(9)/L (no washout required)
• •4. Hemoglobin ≥ 9 g/dL, transfusions may be used to raise Hgb to ≥ 9 g/dL (no washout required)
• •5. Total bilirubin ≤ 1.5 × institutional upper limit of normal (ULN)
• •6. Aspartate transaminase (AST) / alanine transaminase (ALT) ≤ 2.5 × institutional ULN
• •7. Creatinine within normal institutional limits OR creatinine clearance ≥ 30 mL/min/1.73 m2 for patients with creatinine above institutional ULN
• •6. Participants of reproductive potential must agree to using adequate contraception (e.g., hormonal or barrier method of birth control; abstinence, an intrauterine device) for the duration of study participation (including dosing interruptions) and up to 42 days after end of study intervention; or be surgically sterilized (e.g., hysterectomy, tubal ligation, or vasectomy).
• •7. Ability to swallow study agent.
• •8. Ability to understand and willingness to sign an informed consent form.
• •9. Ability and stated willingness to adhere to the study visit schedule and other protocol procedures/requirements for the duration of the study.
• •Inclusion of Minorities and Other Underrepresented Populations Recruitment is open and encouraged to all genders, all minorities, and underrepresented populations. Although distributions may vary by disease type, our recruitment procedures have been developed to enroll participants who are representative of the respective target population.