Methods :
1. all data will be obtained from patients as personal history (name, age, sex, occupation,residence , marital status, personal habits), history of illness at diagnosis, presence of diabetes or hypertension and other co-morbidity
2. general examination as general appearance,vital signs ,head and neck ,chest ,upper and lower limbs, Abdomen and pelvis ,and local examination as per rectal examination.
3. laboratory test as complete blood count and tumor markers ,imaging as abdominal ultrasound, CT,MRI, endoscopic findings and pathological features.
