Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest

This observational study aims to identify early predictors of in-hospital mortality in adult patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest. The study prospectively enrolls patients admitted to the intensive care unit at a tertiary care hospital in Turkey. Various clinical, biochemical, and resuscitation-related parameters will be recorded within the first 24 hours of ICU admission. The primary goal is to determine which factors are most strongly associated with mortality within 30 days. The findings are expected to improve clinical decision-making and risk stratification in the management of post-cardiac arrest patients.

This is a prospective observational study conducted in the intensive care unit (ICU) of Gazi Yaşargil Training and Research Hospital, Turkey. The study aims to identify independent predictors of in-hospital mortality in patients who achieve return of spontaneous circulation (ROSC) after cardiac arrest. Adult patients (age ≥ 18 years) who were resuscitated after cardiac arrest and admitted to the ICU are consecutively included. Data are collected prospectively on admission and within the first 24 hours, including demographic characteristics, cause and type of arrest, time to ROSC, initial rhythm, hemodynamic parameters, neurological status, lactate, pH, base excess, biomarkers, and therapeutic interventions. Primary outcome is 30-day in-hospital mortality. Secondary outcomes include neurological outcome at discharge and ICU length of stay. Patients are followed up until hospital discharge or death. The data will be analyzed using multivariate logistic regression to identify independent risk factors for mortality. The study was approved by the institutional ethics committee, and no intervention beyond routine care is performed. Results are expected to improve clinical prognostication and guide decision-making for patients with ROSC after cardiac arrest.