Loading clinical trials...

Psilocybin With Intracranial Neural Sensing | Clinical Trials | Clareo Health

ENROLLING_BY_INVITATIONPHASE1

Psilocybin With Intracranial Neural Sensing

NCT06919640•Joshua Woolley, MD, PhD

Summary

This is an open-label, single-arm, pilot study exploring the neural, sensory, and cognitive effects of a single, medium dose of psilocybin in patients with chronic pain who already have implanted sensing-capable deep brain stimulation (DBS) devices. Outcomes include multi-site neural recording from previously placed ambulatory sensing-capable DBS devices, quantitative sensory and cognitive testing, and self-reports of pain. We hypothesize that psilocybin will change functional connectivity, decrease clinical and task-based pain reports, and improve cognitive functions.

Detailed Description

Eligibility

Age

21 - 75 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Currently implanted chronic brain sensing device (such as RC+S or Percept)
•Not currently enrolled in another trial
•Ability to speak and read English
•Able to attend all in-person and virtual visits
•No changes in medication or major surgical procedures anticipated for the trial
•Able to identify someone to accompany from the research unit at the end of drug administration day or agreement to have a study team member accompany them from the research unit

Exclusion Criteria

•A health condition that makes this study unsafe or unfeasible, determined by study physicians
•Use of medication, vitamins, or supplements and unwilling or unable to discontinue medications that have problematic interactions with psilocybin
•Adulthood epilepsy or other seizure disorder
•Require supplemental oxygen
•Medical finding or diagnosis that would make participation in this trial unsafe

Locations (1)

University of California, San Francisco

San Francisco, California, United States

Key Dates

Start Date

June 1, 2025

Primary Completion Date

April 30, 2028

Completion Date

April 30, 2028

Last Updated

June 6, 2025

Enrollment

ESTIMATED participants

Conditions

Chronic Pain

Interventions

Psilocybin

DRUG

Optimization of NIBS for Treatment of Addiction

NCT04379115

Opioid-use DisorderChronic Pain

View study

RECRUITINGNA

VR Mindfulness Training for Veterans With SCI

NCT06587607

Spinal Cord InjuryChronic Pain

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 6, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Psilocybin With Intracranial Neural Sensing

Inclusion Criteria

Exclusion Criteria

Optimization of NIBS for Treatment of Addiction

VR Mindfulness Training for Veterans With SCI

CIH Stepped Care for Co-occurring Chronic Pain and PTSD

Personalized High-Definition tDCS Protocols for Chronic Pain Treatment

Osteopathic Manual Therapy vs Ganglion Impar Block for Chronic Coccydynia

Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)