Teclistamab Plus Autologous Lymphocyte Infusion (ALI) for the Treatment of R/R Multiple Myeloma

Exclusion Criteria

• •• Previous treatment with \> 2 lines of therapy
• •* Patient has active central nervous system involvement with MM
• •* Received any prior BCMA-directed therapy
• •* Received the following prior antimyeloma therapy, within the specified time frame prior to enrollment:
• •* Targeted therapy, epigenetic therapy, or treatment with an investigational drug or an invasive investigational medical device within 21 days or ≥5 half-lives, whichever is less
• •* Investigational vaccine within 4 weeks
• •* Monoclonal antibody therapy within 21 days
• •* Cytotoxic therapy within 21 days
• •* PI therapy within 14 days
• •* IMiD agent therapy within 14 days
• •* Radiotherapy within 14 days or focal radiation within 7 days
• •* Gene-modified adoptive cell therapy (eg, chimeric antigen receptor modified T cells, NK cells) within 3 months
• •* Stem cell transplant:
• •* previous allogeneic stem cell transplant
• •* autologous stem cell transplant performed within 12 weeks
• •* Patients with plasma cell leukemia (presence of 5% or more plasma cells in conventional peripheral blood smear white blood cell differential count)
• •* Contraindications or life-threatening allergies, hypersensitivity, or intolerance to any study drug or its excipients
• •* Any ongoing myelodysplastic syndrome or B-cell malignancy (other than MM)
• •* Any history of malignancy, other than MM, which is considered at high risk of recurrence requiring systemic therapy
• •* Any active malignancy (ie, progressing or requiring treatment change in the last 24 months) other than MM. The only allowed exceptions are malignancies treated within the last 24 months that are considered cured:
• •* Non-muscle invasive bladder cancer (solitary Ta-PUNLMP or low grade, \<3 cm, no CIS)
• •* Non-melanoma skin cancers treated with curative therapy or localized melanoma treated with curative surgical resection alone
• •* Non-invasive cervical cancer
• •* Breast cancer: adequately treated lobular carcinoma in situ or ductal carcinoma in situ, or history of localized breast cancer (anti-hormonal therapy is permitted)
• •* Localized prostate cancer (M0, N0) with a Gleason Score ≤7a, treated locally only (RP/RT/focal treatment)
• •* Other malignancy that is considered cured with minimal risk of recurrence in consultation with the treating physician
• •* Clinically relevant and active liver or renal insufficiency; significant cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, rheumatologic, hematologic, psychiatric, or metabolic disturbances
• •* Patient has any other concurrent severe and/or uncontrolled medical condition(s) (e.g., uncontrolled diabetes mellitus, uncontrolled hypertension, active/symptomatic coronary artery disease, chronic obstructive pulmonary disease (COPD), active hemorrhage, psychiatric illness, active or uncontrolled infection that in the investigator opinion places the patient at unacceptable risk and would prevent the subject from signing the informed consent form
• •* Participant had major surgery or had significant traumatic injury within 2 weeks prior to enrollment, or will not have fully recovered from surgery, or has major surgery planned during the time the participant is expected to be treated in the study.
• •* Acute active infection requiring treatment (systemic antibiotics, antivirals, or antifungals) within 14 days prior to enrollment
• •* Patient has a known history of HIV seropositivity
• •* Seropositive for hepatitis B: defined by a positive test for HbsAg. Participants with resolved infection (ie, participants who are HbsAg negative with antibodies to total anti-HBc with or without the presence of anti-HBs) must be screened using RT-PCR measurement of HBV DNA levels. Participants with a known history of HBV infection must be screened using RT-PCR measurement of HBV DNA levels irrespective of serological results. Those who are RT-PCR positive will be excluded. Participants with serologic findings suggestive of HBV vaccination (anti-HBs positivity as the only serologic marker) AND a known history of prior HBV vaccination, do not need to be tested for HBV DNA by RT-PCR (see Appendix 12).
• •* Active hepatitis C infection as measured by positive HCV-RNA testing. Participants with a history of HCV antibody positivity must undergo HCV-RNA testing. If a participant with history of chronic hepatitis C infection (defined as both HCV antibody and HCV-RNA positive) completed antiviral therapy and has undetectable HCV-RNA 12 weeks following the completion of therapy, the participant is eligible for the study.