Prof. Khan Abul Kalam Azad, MBBS, FCPS, MD(Med), FACP(USA)

CONTACT

Lead Sponsor

Dr. Md. Alimur Reza

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

No

•Male or female patients aged between 18 to 65 years.
•Have an acute illness (less than or equal to 7 days duration) with any of the following signs and symptoms consistent with a lower respiratory tract infection (new or worsening):
•1. Fever (body temperature \> 38.0 °C (100.4 °F) measured orally)
•2. Shortness of breath
•3. New onset or increased cough with or without sputum production.
•4. Chest pain.
•Have radiographically documented bacterial pneumonia:
•1. Infiltrates in a unilateral, lobar distribution
•2. Diffuse opacities or white condensed area
•3. The alveoli fill with white inflammatory fluid

•Patients with severe pneumonia (Clinical \& Radiological Assessment)
•Patients with suspicion of viral pneumonia (bilateral, patchy opacities, etc., in chest radiography.)
•Patients with suspicion of nosocomial pneumonia, aspiration pneumonia, etc.
•History of hypersensitivity, known or suspected contraindications, or intolerance to any of the study drugs.
•Intake of an antibiotic within the last 48 hours before study admission.
•History of hospitalization within the last 28 days.
•Patients in pregnancy and lactational state.
•Patients with Renal impairment (screening eGFR \< 30mL/min).
•Significant hepatic impairment (Alanine aminotransferase \> three times the upper limit of normal).
•Serious diseases that affect the immune system, such as Acquired Immunodeficiency Syndrome (AIDS), cancer, etc.
•Patients who are taking steroid medications, at least 20 mg daily dose of prednisolone (or equivalent doses of other glucocorticoids).
•Patients who are accepting chemotherapy or anti-cancer therapy or plan to receive such treatment during the trial or six months prior to enrollment.
•Had epilepsy, stroke, or other central nervous system disorders or uncontrolled psychiatric history.