PsiloIMAGINE: A Psychedelic-augmented Mental Imagery-based Intervention for Young People With Self-harm

Exclusion Criteria

• •Current or past history of psychosis or mania in themselves or a first-degree relative
• •Current severe suicidal ideation that constitutes a risk for their participation
• •Have a medically significant condition which renders them unsuitable for the psychedelic component of the study (e.g., hypertension, diabetes, severe cardiovascular disease, hepatic or renal failure etc.)
• •Previous psychedelic use
• •Current or chronic history of kidney or liver disease
• •Have previously experienced a serious adverse response after psychedelic use
• •Intoxication on any of the visits, as assessed by difficulty in walking, the slurring of speech, difficulty concentrating or drowsiness
• •Clinically significant head injury (e.g., requiring medical or surgical intervention) that in the opinion of the investigators, contraindicates their participation
• •Severe learning disability (including dyslexia/dyspraxia) that needs support to perform daily work/school tasks
• •Unwillingness or inability to follow the procedures outlined in the protocol
• •Are currently using a psychoactive medication
• •History of psychosurgery
• •In the opinion of the study team, they are unlikely to comply with the study protocol and lifestyle restrictions that it imposes
• •Unstable physical illness
• •Heavy smoker
• •Those needing regular specified medication that might interact adversely with psilocybin e.g., selective serotonin reuptake inhibitor, 5HT1 agonists, mirtazapine, trazodone, analgesics that have serotonergic effects (tramadol), MAOI's, antipsychotics with significant 5-HT2A receptor antagonist actions (risperidone, olanzapine, and quetiapine)
• •Those unwilling to allow their GP or involved mental health practitioners to be informed of their participation
• •Women of childbearing age who are not using reliable contraceptive methods
• •Women of childbearing age who are unable to comply with or produce a positive pregnancy urine test