Implementation of a New Algorithm for HRR Gene Mutation Testing in Patients With mPC Through Liquid Biopsy Integration

Implementation of a New Algorithm for HRR Gene Mutation Testing in Patients With mPC

NCT06762379•European Institute of Oncology

View on ClinicalTrials.gov

Summary

Implementation of a new algorithm for HRR gene mutation testing in patients with mPC through liquid biopsy integration

Detailed Description

Analysis of the current clinical landscape of mPC Italy to identify gaps and opportunities for improvement. Patient identification and enrollment Blood sample collection and plasma purification ctDNA extraction and NGS analysis of homologous recombination repair (HRR) genes. Clinical Real-World Data (RWD) and molecular analysis data collection Testing algorithm development based on collected data Finalization and sharing of a best practice model for diagnostic procedures in mPC patients

Eligibility

Age

18 - No limit years

Sex

MALE

Healthy Volunteers

Inclusion Criteria

•Patients with metastatic prostate cancer whose tumor tissue is unavailable or inadequate for molecular testing. • Written informed consent must be signed and dated by the patient and the investigator prior to inclusion.

Exclusion Criteria

•Unable to provide written informed consent

Locations (1)

European Institute of oncology

Milan, Italy

Key Dates

Start Date

December 20, 2024

Primary Completion Date

December 31, 2027

Completion Date

December 31, 2030

Last Updated

January 7, 2025

Enrollment

125

ESTIMATED participants

Conditions

Metastatic Prostate Cancer (mPC)

Contacts

Elena Guerini Rocco, MD

CONTACT

00390294372871 elena.guerinirocco@ieo.it

francesca lombardi, biologist

CONTACT

00390257489425 francesca.lombardi@ieo.it

[68Ga]Ga-P17-079 in the Diagnosis and Treatment of Metastatic Prostate Cancer

NCT06864572

Metastatic Prostate Cancer (mPC)

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 7, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions