UCMSCs Combined With Allogeneic Islet Transplantation for the Treatment of Diabetes

Exclusion Criteria

• •1. Diabetic ketoacidosis that is not yet controlled.
• •2. Severe allergic constitution, meaning prone to allergic reactions without a clear and identifiable cause.
• •3. BMI \< 14 or \> 35.
• •4. Severe anemia (hemoglobin \< 8 g/dL in males, \< 7 g/dL in females).
• •5. HIV-positive, carriers of viral hepatitis or in the active phase, or other uncontrolled infectious diseases.
• •6. History of acute pancreatitis, pulmonary embolism, or other thrombotic diseases, as well as severe heart, liver, kidney, respiratory, or neurological diseases.
• •7. Patients with gestational diabetes, monogenic diabetes, diabetes due to pancreatic damage, or other secondary diabetes (e.g., diabetes caused by Cushing's syndrome, thyroid dysfunction, or acromegaly).
• •8. Pregnant women or those planning pregnancy within 3 months before or after treatment, and women who are breastfeeding.
• •9. Patients with mental illness, alcohol or drug abuse, who are unable to cooperate with treatment.
• •10. Known or suspected tumors.
• •11. History of other autoimmune diseases or hematological disorders.
• •12. Any other clinical conditions that, in the investigator's judgment, may pose a risk to the participant's safety.