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To Observe the Clinical Effect of Femoral Nerve Block With Low Concentration Ropivacaine Under Ultrasound Guidance Combined With Neurostimulator Based on DPN Grading
The purpose of this study was to quantitatively standardize the performance of patients with DPN with different course of disease using high-frequency ultrasound, and to design experiments to verify the conclusion that DPN patients with peripheral nerve damage increased nerve sensitivity to local anesthetic drugs and increased block time, and to achieve the same blocking effect by using low-concentration local anesthetic drugs, so as to reduce the probability of complications such as transient nerve injury, severe nerve injury, and local anesthetic poisoning.
Clinically, through the correlation study between the serum choliphin concentration and the degree of neuropathy (cross-sectional area) of patients with DPN (scale standardization) of different course of disease and the degree of neuropathy under ultrasound, the DPN was standardized after conclusion, and then the clinical study was designed to use low concentrations of ropivacaine to perform nerve blocks at the same site in patients with DPN of different grades, and the time t of the first use of the analgesic pump after the primary outcome measures, the electrical stimulation threshold during nerve block, and the secondary outcome indicators were the threshold of electrical stimulation during nerve block, Sensory and motor block time-to-occur to assess the effect of nerve block.
Age
55 - 85 years
Sex
ALL
Healthy Volunteers
Yes
Second Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
Start Date
August 20, 2025
Primary Completion Date
August 20, 2025
Completion Date
October 29, 2025
Last Updated
August 3, 2025
60
ESTIMATED participants
Different DPN ratings
OTHER
Lead Sponsor
Zheng Guo
NCT06959901
NCT06574035
Data Source & Attribution
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View ClinicalTrials.gov Terms and ConditionsNCT06861062