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TeSE (Testicular Sperm Extraction) in Azoospermic Patients: m-TeSE vs. l-TeSE | Clinical Trials | Clareo Health

COMPLETEDNA

TeSE (Testicular Sperm Extraction) in Azoospermic Patients: m-TeSE vs. l-TeSE

Preliminary Results of Microsurgical Testicular Exploration for Sperm Retrieval in Azoospermic Patients: A Randomized Controlled Trial Comparing Operating Microscope vs. Surgical Loupes

NCT06702397•A.O.U. Città della Salute e della Scienza

View on ClinicalTrials.gov

Summary

The aim of the study is to compare surgical outcomes (intra and post-operative complications) and sperm retrieval rates between conventional microsurgical-assisted testicular sperm extraction (m-TeSE - Group A) and testicular sperm extraction performed with surgical loupes (l-TeSE - Group B) in adult males with non-obstructive azoospermia.

Detailed Description

Objective: To compare surgical outcomes and sperm retrieval rates (SRR) between conventional microsurgical-assisted testicular sperm extraction (m-TeSE - Group A) and testicular sperm extraction performed with surgical loupes (l-TeSE - Group B) in adult males with non-obstructive azoospermia (NOA). A multicentric prospective randomized trial was conducted from March 2022. Adult males with NOA without genetic alterations who agreed to participate in the study and signed the required informed consent were enrolled. SRR, intra and post-operative complications (according to Clavien-Dindo classification), hormonal profile tchanges were considered as outcomes during the follow up period.

Eligibility

Age

18 - No limit years

Sex

MALE

Healthy Volunteers

Inclusion Criteria

•Adult males
•Diagnosis of non obstructive azoospermia who required m-TeSE.

Exclusion Criteria

•Absence of signed written informed consent
•Age \< 18 years
•Obstructive azoospermia
•Genetic anomalies (e.g., Klinefelter syndrome, Kallmann syndrome, Y chromosome microdeletions, CFTR mutations)
•Previous testicular biopsies/surgical sperm retrieval
•Personal history of malignant testicular tumor
•Unilateral cryptorchidism
•Varicocele
•Previous chemotherapy/radiotherapy treatments
•Monorchidism

Locations (1)

Molinette - AOU Città della Salute e della Scienza di Torino

Turin, Italy

Key Dates

Start Date

March 1, 2022

Primary Completion Date

April 30, 2024

Completion Date

April 30, 2024

Last Updated

November 25, 2024

Enrollment

ACTUAL participants

Conditions

Azoospermia, Nonobstructive

Interventions

Microscope

DEVICE

Surgical loupes

DEVICE

Autologous Transplantation of Human Cryopreserved Testis Tissue

NCT07364409

CancerHematologic Diseases+2 more

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COMPLETED

Machine Learning Based-Personalized Prediction of Sperm Retrieval Success Rate

NCT06358794

Infertility, MaleAzoospermia, Nonobstructive

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 25, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

TeSE (Testicular Sperm Extraction) in Azoospermic Patients: m-TeSE vs. l-TeSE

Inclusion Criteria

Exclusion Criteria

Autologous Transplantation of Human Cryopreserved Testis Tissue

Machine Learning Based-Personalized Prediction of Sperm Retrieval Success Rate

The Effects of Intratesticular PRP Injection in Men With Azoospermia or Cryptozoospermia

Seminal TEX101 as a Predictor of Recovery of Spermatogenesis in Azoospermic Men With Palpable Varicocele

TESE and Non Obstructive Azoospermia