Efficacy and Safety of Additive Manufacturing Personalized Titanium Mesh in Guided Bone Regeneration

Exclusion Criteria

• •1. Patients with edentulism.
• •2. Patients with mild bone defects (residual alveolar ridge width greater than 3 mm).
• •3. Presence of acute or chronic infection in the surgical area.
• •4. Presence of acute or chronic infection in the teeth adjacent to the edentulous area.
• •5. Participation in similar trials or other interventional clinical trials within 30 days prior to signing the informed consent form.
• •6. History of metal allergies, severe allergy history, or severe immune deficiency.
• •7. Uncontrolled metabolic diseases, such as Type 1 diabetes or Type 2 diabetes (HbA1c ≥ 7% or fasting blood glucose ≥ 7 mmol/L despite medication control), severe liver or kidney dysfunction (ALT, AST \> 2 times the upper limit of normal, serum creatinine above the upper limit of normal).
• •8. Long-term use of steroid medications.
• •9. History of drug abuse or alcoholism.
• •10. Pregnant or breastfeeding women.
• •11. Poor compliance.
• •12. Other conditions deemed unsuitable for participation by the investigator.