Efficacy of Seluang Fish Oil (Rasbora Argyrotaenia) and Synbiotics Supplementation on CD4+CD25+ Foxp3+ T-regulator Cells, IL17/IL-10 Ratio, and Disease Activity in Systemic Lupus Erythematosus Patients

Lead Sponsor

Universitas Sriwijaya

Age

18 - 55 years

Sex

ALL

Healthy Volunteers

No

•Patients who meet the SLICC criteria
•Patients with mild to moderate SLE (mild if SLEDAI-2K score \< 6 and moderate if SLEDAI-2K score: 6-12)
•Aged 18-55 years
•Willing to stop consuming vitamin D or multivitamin supplements containing vitamin D for at least 3 weeks before participating in the study
•Willing to stop consuming probiotics that were previously taken for at least 1 week before participating in the study
•If using prednisone, the dose must be stable (corticosteroid equivalent ≤ 20 mg/day) for at least 4 weeks before the study
•Willing to sign informed consent

•Patients with severe SLE
•Patients with SLE with hypercalcemia (\> 2.60 mmol/l)
•Patients with SLE with liver dysfunction: serum Aspartate Transferase (AST) - and Alanine Transferase (ALT) levels \> 2 times the normal value or total serum bilirubin \> 1.5 times the normal value
•Patients undergoing hemodialysis or patients with serum creatinine \> 2.5 mg/dL
•Pregnant patients
•Patients with SLE with immunocompromised conditions such as HIV
•Patients with SLE with chronic infections such as pulmonary tuberculosis
•Patients currently undergoing antibiotic therapy
•Drop out criteria:
•Patients who have been off medication for more than 3 weeks
•Patients who have passed away
•Patients who consume yogurt or supplements containing probiotics/synbiotics more than once consecutively in 1 week
•Patients who experience a change in immunosuppressive agents during the study
•Patients who are hospitalized due to a worsening condition during the intervention period
•Loss to follow-up

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