Clareo Health | Efficacy of Seluang Fish Oil (Rasbora Argyrotaenia) and Synbiotics Supplementation on CD4+CD25+ Foxp3+ T-regulator Cells, IL17/IL-10 Ratio, and Disease Activity in Systemic Lupus Erythematosus Patients
Efficacy of Seluang Fish Oil (Rasbora Argyrotaenia) and Synbiotics Supplementation on CD4+CD25+ Foxp3+ T-regulator Cells, IL17/IL-10 Ratio, and Disease Activity in Systemic Lupus Erythematosus Patients
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Universitas Sriwijaya
Age
18–55
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients who meet the SLICC criteria
Patients with mild to moderate SLE (mild if SLEDAI-2K score \< 6 and moderate if SLEDAI-2K score: 6-12)
Aged 18-55 years
Willing to stop consuming vitamin D or multivitamin supplements containing vitamin D for at least 3 weeks before participating in the study
Willing to stop consuming probiotics that were previously taken for at least 1 week before participating in the study
If using prednisone, the dose must be stable (corticosteroid equivalent ≤ 20 mg/day) for at least 4 weeks before the study
Willing to sign informed consent
You may not be if
Patients with severe SLE
Patients with SLE with hypercalcemia (\> 2.60 mmol/l)
Patients with SLE with liver dysfunction: serum Aspartate Transferase (AST) - and Alanine Transferase (ALT) levels \> 2 times the normal value or total serum bilirubin \> 1.5 times the normal value
Patients undergoing hemodialysis or patients with serum creatinine \> 2.5 mg/dL
Pregnant patients
Patients with SLE with immunocompromised conditions such as HIV
Patients with SLE with chronic infections such as pulmonary tuberculosis
Patients currently undergoing antibiotic therapy
Drop out criteria:
Patients who have been off medication for more than 3 weeks
Patients who have passed away
Patients who consume yogurt or supplements containing probiotics/synbiotics more than once consecutively in 1 week
Patients who experience a change in immunosuppressive agents during the study
Patients who are hospitalized due to a worsening condition during the intervention period
