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Acute Effects of Cold Exposure on Cardiovascular System | Clinical Trials | Clareo Health

RECRUITINGNA

Acute Effects of Cold Exposure on Cardiovascular System

Acute Effects of Cold Exposure on Cardiovascular System and Potential Mechanism in Healthy Young Adults: A Randomized Controlled Study

NCT06652425•Fudan University

View on ClinicalTrials.gov

Summary

This is a randomized controlled human exposure crossover study. Investigators aim to assess the acute effects of low temperature exposure on cardiovascular system and the underlying mechanisms.

Detailed Description

The investigators will conduct a randomized controlled human exposure crossover study among about 40 healthy young adults in Shanghai, China. Each subject will be exposed twice: once to the low temperature (15°C) and once to the moderate temperature (22°C) in a chamber for about 2 hours. During the exposure session, each subject will be requested to rest. Health examinations will be conducted at baseline immediately prior to exposure, during the period of exposure, and after exposure. Health examinations include blood pressure tests and Holter monitoring. Investigators plan to collect blood and urine samples.

Eligibility

Age

18 - 30 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Living in Shanghai during the study period;
•Body mass index \> 18.5 and ≤ 28;
•Right-handed;
•Receiving or having received higher education;
•With the ability to read and understand Chinese smoothly.

Exclusion Criteria

•Smoking and alcohol abuse;
•Current drug and dietary supplements intake;
•Subjects with allergic diseases, such as allergic rhinitis, allergic asthma, and atopy;
•Subjects with cardiovascular diseases, such as congenital heart disease, pulmonary heart disease, and hypertension;
•Subjects with respiratory diseases, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease;
•Subjects with chronic diseases, such as diabetes, chronic hepatitis, and kidney disease;
•Subjects who have a history of major surgery due to cardiovascular, cerebrovascular, respiratory, or neurological diseases;
•Subjects with neurologic disorders, such as stroke, traumatic brain injury, epilepsy, and schizophrenia;
•Abnormal spirometry (FEV1 and FVC ≤ 75% of predicted and FEV1/FVC ≤ 0.65);
•Subjects with color vision disabilities.

Locations (1)

Department of Environmental Health, School of Public Health, Fudan University

Shanghai, Shanghai Municipality, China

Key Dates

Start Date

October 16, 2024

Primary Completion Date

November 16, 2024

Completion Date

December 31, 2026

Last Updated

February 27, 2025

Enrollment

ESTIMATED participants

Conditions

Cardiovascular System

Interventions

Low temperature (15°C) group

OTHER

Moderate temperature (22°C) group

OTHER

Contacts

Renjie Chen, PhD

CONTACT

+86-021-54237908 chenrenjie@fudan.edu.cn

Haidong Kan, PhD

CONTACT

+86-021-54237908 kanh@fudan.edu.cn

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 27, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Acute Effects of Cold Exposure on Cardiovascular System

Inclusion Criteria

Exclusion Criteria

Prospective Evaluation on the Role Exerted by Hormonal Contraceptives on 24-h Blood Pressure. A Prospective Observational Study

Acute Effects of Meteorological Factors and Air Pollution on Cardiovascular Health

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