Cryoablation with or Without Serplulimab in Treating Patients with Stage I-IIA Non-small Cell Lung Cancer

Exclusion Criteria

• •1. Patients with poor cardiopulmonary function or other comorbidities who cannot tolerate multimode thermal therapy;
• •2. Patients whose chest CT indicated that the lung lesions could not be reached percutaneously or transbronchially;
• •3. Severe liver and kidney function and coagulation function abnormalities, platelet count \<70×109/L;
• •4. Patients who have received other anti-tumor drugs in the past 6 months or have used immune checkpoint inhibitors before;
• •5. The patient has an uncontrolled disease (including but not limited to active infection, symptomatic congestive heart failure, unstable angina, arrhythmia, mental illness, etc.);
• •6. Primary immune deficiency or autoimmune diseases (e.g. rheumatoid arthritis, systemic lupus erythematosus, etc.);
• •7. Pregnant and lactating women;
• •8. Long-term use of steroid;
• •9. Other circumstances considered inappropriate for participation in this study.