Combining rTMS and tDCS in Depression: an Exploratory Clinical Trial

Exclusion Criteria

• •Primary psychiatric diagnosis other than single episode depressive disorder or recurrent depressive disorder.
• •History of schizophrenia or schizoaffective disorders.
• •Any history of psychotic symptoms in the current or previous depressive episodes.
• •History of obsessive-compulsive disorder.
• •History of autism spectrum disorder.
• •History of intractable migraine.
• •Clinical conditions that would increase risks associated with receiving high-dose iTBS.
• •Cochlear implants.
• •Epilepsy.
• •Pacemakers.
• •Presence of metal in the head, especially of a ferromagnetic type.
• •Presence of magnetically controlled implantable devices.
• •Current drug misuse (F10-F19).
• •History of positive screening urine test for drugs of abuse at screening: cocaine, amphetamines, barbiturates, opiates.
• •Current (or chronic) use of opiates.
• •Prior nonresponse to rTMS.
• •Prior nonresponse to Electroconvulsive Therapy (ECT).
• •Female that is pregnant or breastfeeding.
• •Female with a positive pregnancy test at participation.
• •History of psychosurgery for depression.
• •Damage to- or diseases of the skin, which affects the scalp. E.g. Psoriasis or open wounds.
• •No changes in psychotropic medication during the study will be allowed, with the exception of the ones due to intolerability.