The Effects of Semaglutide on Body Composition and Performance in Military Personnel

Exclusion Criteria

• •Currently in Basic Combat Training, Advanced Individual Training, or One Station Unit Training, or equivalence in other military services.
• •Current or history of Type 1 or Type 2 Diabetes, cardiovascular (e.g., heart disease, peripheral artery disease), musculoskeletal (e.g., myopathies), immune (e.g., lupus, asthma), gastrointestinal (e.g., irritable bowel syndrome, pancreatitis), neurological (e.g., dystonia), pulmonary (pulmonary fibrosis, COPD, lung cancer), or renal diseases (e.g., kidney diseases), and eating disorders (e.g., bulimia nervosa, anorexia nervosa).
• •History of cholecystectomy
• •Personal or family history of medullary thyroid carcinoma or those with multiple endocrine neoplasia type 2.
• •Participants who are pregnant or breastfeeding, or those who may be pregnant or were pregnant in the last 12 months.
• •Male and female participants who plan or will attempt to become pregnant or help conceive a child within two months of treatment.
• •Inability to exercise ≥ 3x per week during the study.
• •Currently taking or history of routine use of medications known to affect metabolism or performance (e.g., thiazide diuretics, oral steroids, testosterone replacement therapy, etc.).
• •Self-reported change in body weight ≥ 5 kg within 90 days before screening.
• •Treatment with any medication for the indication of obesity within 90 days before screening.
• •Treatment with other orally administered medications such as sulfonylureas, sitagliptin, phenytoin, levothyroxine, albuterol, prednisone, and other drugs as identified during screening by the medical screening and staff.
• •Current or previously suspected alcohol abuse (defined as Harmful Use by the World Health Organization), those who meet criteria for alcohol abuse disorder (as outlined in the DSM-5), or other substance abuse (i.e., the use of illegal drugs or the use of prescription or over-the-counter drugs for purposes other than those for which they are meant to be used, or in excessive amounts.
• •History of major depressive disorder.
• •Participants with implanted or external electrical devices (e.g., pacemakers).
• •On a specialized diet (e.g., keto, intermittent fasting).
• •Claustrophobia or difficulty breathing with a face mask.
• •Known or suspected hypersensitivity to study product(s) or related products.