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Adversity, Brain and Opioid Use Study | Clinical Trials | Clareo Health

RECRUITINGNA

Adversity, Brain and Opioid Use Study

A Mechanistic Investigation of Risk Factors for Opioid Use Disorder: Examining Hippocampal-based Context-dependent Learning and Memory Associated With Adverse Childhood Experiences

NCT06355778•University of Michigan

View on ClinicalTrials.gov

Summary

The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and healthy adults that do not have an Opioid Use Disorder and are not taking buprenorphine.

Eligibility

Age

18 - 55 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Right handed
•Able to give informed consent
•Normal/corrected-to-normal vision and hearing
•Diagnosis of OUD
•Be actively receiving buprenorphine (BUP) for opioid agonist therapy
•Be free from illicit substance use for at least 2 weeks
•The study will allow stable dose (\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol)
•Taking BUP for chronic pain
•No Substance Use Disorder (including OUD)
•The study will allow stable dose (\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol)
+2 more criteria

Exclusion Criteria

•Significant medical or neurologic conditions (e.g., stroke, seizures, multiple sclerosis)
•Actively suicidal
•Contraindication for MRI
•Inability to tolerate small, enclosed spaces without anxiety
•Life history of schizophrenia, bipolar disorder, learning disability, attention deficit disorder, or pervasive developmental disorder
•Use of substances or prescription medications that could interfere with measures of interest (per protocol)
•Unable to provide informed consent
•Participants who have completed other studies in our lab involving learning and memory assessments with the same/similar tasks used here (HUM00230585, HUM00121812) will not be eligible to complete the current study, due to possible learning/practice effects
•Unable to fit comfortably in the MRI scanner due to body size (typically men over 6 feet tall that weigh more than 250 lbs, men under 6 feet tall that weigh over 220 lbs, women over 5'11" tall that weigh more than 220 lbs, or women under 5'10" tall that weigh more than 200 lbs).

Locations (1)

University of Michigan

Ann Arbor, Michigan, United States

Key Dates

Start Date

January 9, 2025

Primary Completion Date

April 1, 2028

Completion Date

April 1, 2028

Last Updated

December 12, 2025

Enrollment

185

ESTIMATED participants

Conditions

Opioid Use DisorderHealthy

Interventions

Magnetic Resonance Imaging (MRI)

OTHER

Computer Tasks

BEHAVIORAL

Contacts

Aml Almamri

CONTACT

734-232-4166 AdversityBrainOUD@med.umich.edu

Madeline Vincent

CONTACT

734-232-0190 AdversityBrainOUD@med.umich.edu

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HealthyRespiratory Disease

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Healthy Volunteer

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RECRUITINGPHASE1

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 12, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Adversity, Brain and Opioid Use Study

Inclusion Criteria

Exclusion Criteria

A New Portable Device for Non-invasive Ventilatory Support

Collection of Data and Samples From Healthy Donors for Use in Translational Research

Research Into the Safety of a New Agent (VT-5006) in People With and Without Parkinson's Disease

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