Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Northside Hospital, Inc.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Availability of a 4/8 - 6/8 HLA-matched related donor or a 7/8 HLA-matched unrelated donor
Receiving first allogeneic transplant
KPS \>/= 70%
MDS associated with TP53 mutation AND R-IPSS high or very high risk at diagnosis OR
AML with adverse risk cytogenetics or molecular abnormalities according to the 2017 ELN risk stratification OR pre-transplant MRD by either flow cytometry, cytogenetics or FISH
Less than 5% myeloblasts in the marrow pre-transplant
You may not be if
Poor cardiac function defined as LVEF \<45%
Poor pulmonary function defined as FEV1, FVC, or DLCO \<50% predicted
Poor liver function defined as bilirubin \>/=2.5mg/dL, AST/ALT \>3xULN
Poor renal function defined as creatinine \>/=2.0mg/dL or CrCl \<40mL/min
Ongoing or active systemic infection, active Hepatitis B or C virus infection, or known HIV positivity
Patient requiring treatment with a moderate or strong inhibitor or inducer of CYP3A4 or a P-gp inhibitor within 7 days prior to starting preparative chemotherapy through Day +4 post-transplant
