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Time and Nutrient-Dependent Effects of Aerobic Exercise on Metabolism in Adults (TANDEM Study) | Clinical Trials | Clareo Health

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Time and Nutrient-Dependent Effects of Aerobic Exercise on Metabolism in Adults (TANDEM Study)

Examining Time and Nutrient Dependent Effects of Aerobic Exercise on Energy Metabolism in Adults With Overweight and Obesity

NCT06311487•University of Colorado, Denver

View on ClinicalTrials.gov

Summary

This study plans to learn more about metabolic responses to aerobic exercise at different times of the day (morning or evening) under fasting versus fed conditions.

Detailed Description

This study plans to learn more about metabolic responses to aerobic exercise at different times of the day (morning or evening) under fasting versus fed conditions. Specifically, the investigators will explore the effect of fasted and fed AM and PM aerobic exercise on exercise energy expenditure and substrate oxidation, explore the effect of fasted and fed AM and PM aerobic exercise on plasma metabolites and lipids, and explore the effect of fasted-AM and Fasted-PM on 24h energy expenditure, 24h substrate metabolism, 24h glucose, and 24h profiles of hormonal regulators of energy metabolism

Eligibility

Age

18 - 40 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Age 18-40 years
•Body Mass Index 18.5-\<40 kg/m2
•Recreationally active: defined as \>100 minutes per week of voluntary exercise at moderate intensity or greater and \>60 min per day of total habitual physical activity (i.e., work related, transportation related) at moderate intensity or greater, over the past 3 months.
•No self-report of acute or chronic disease (cardiovascular disease (CVD), diabetes, pulmonary, gastrointestinal disorders, and orthopedic problems in particular).
•No plans to relocate within the next 6 months.
•No plans for extended travel (\>2 weeks) within the next 6 months.
•Live or work within 30 minutes of the AHWC (exceptions may be made at the discretion of the Study PI on a case-by-case basis for highly motivated subjects).

Exclusion Criteria

•Have a primary care physician (or are willing to establish care with a primary care physician prior to study enrollment) to address medical issues which may arise during screening or study procedures.
•No contraindications to exercise or limitations on ability to be physically active.
•Ability to complete AM or PM exercise and complete 4 exercise sessions per week.
•Ability to adhere to eating and exercise protocols (meal timing, exercising in fasted and fed states)
•Willing and able to wear activity/sleep monitor for 7 consecutive days.
•Willing not to enroll in any other formal weight loss or physical activity programs over the next 6 months.
•For Females:
•Not currently pregnant or lactating.
•Not pregnant within the past 6 months.
•Not planning to become pregnant in the next 6 months
+28 more criteria

Locations (1)

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

Key Dates

Start Date

April 15, 2024

Primary Completion Date

March 1, 2026

Completion Date

March 1, 2026

Last Updated

December 19, 2025

Enrollment

ACTUAL participants

Conditions

Overweight and ObesityHealthy

Interventions

Fasted-AM

BEHAVIORAL

Fed-AM

BEHAVIORAL

Fasted-PM

BEHAVIORAL

Fed-PM

BEHAVIORAL

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 19, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Time and Nutrient-Dependent Effects of Aerobic Exercise on Metabolism in Adults (TANDEM Study)

Inclusion Criteria

Exclusion Criteria

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