Effect of Opioid-free Analgesia and Anesthesia on the Quality of Postoperative Recovery and Nausea Vomit in Patients Receiving Laparoscopic Sleeve Gastrectomy

Exclusion Criteria

• •chronic pain;
• •severe liver dysfunction (total bilirubin 2 mg dl-1);
• •severe renal dysfunction (glomerular filtration rate 60ml min-1 1.73m-2);
• •pregnancy or lactation;
• •preoperative heart rate \<50 beats / min, sick sinus syndrome, severe heart block; -dementia or significant neurological disorders (such as stroke, epilepsy, intracranial tumors, PD, etc.);
• •history of alcohol or drug abuse