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Effect of Paracetamol and Mannitol Injection on Postoperative Analgesia in Patients With Thoracoscopic Lobectomy | Clinical Trials | Clareo Health

NOT_YET_RECRUITINGNA

Effect of Paracetamol and Mannitol Injection on Postoperative Analgesia in Patients With Thoracoscopic Lobectomy

NCT06304181•The Fourth Affiliated Hospital of Zhejiang University School of Medicine

View on ClinicalTrials.gov

Summary

This study thoroughly evaluates the efficacy of acetaminophen mannitol injection for postoperative analgesia in patients undergoing thoracoscopic lobectomy, by comparing it with a control group.

Eligibility

Age

18 - 60 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Obtain informed consent；
•2. Patients scheduled for partial lobectomy under thoracoscopy with general anesthesia；
•3. Classified as American Society of Anesthesiologists (ASA) physical status I\~II；
•4. Age over 18 years；
•5. Patients voluntarily participate and sign the informed consent form

Exclusion Criteria

•1. Systolic blood pressure ≥180 mm Hg or \<90 mm Hg, diastolic blood pressure ≥110 mm Hg or \<60 mmHg
•2. heart rate \<50 beats/min；
•3. Patients with severe liver or kidney dysfunction (severe liver dysfunction: ALT, conjugated bilirubin, AST, ALP, total bilirubin any one \>2 times the upper limit of normal
•4. severe kidney dysfunction: creatinine clearance \<60 ml/min)；
•5. Patients with diabetes and complications (diabetic ketoacidosis, hyperosmolar coma, various infections, major vascular changes, diabetic nephropathy, retinopathy, diabetic cardiomyopathy, diabetic neuropathy, diabetic foot, etc.)；
•6. Patients with severe pulmonary impairment, such as asthma or chronic obstructive pulmonary disease；
•7. History of psychiatric illness or long-term use of psychiatric drugs, chronic pain medication, or history of alcohol abuse；
•8. Neuromuscular diseases；
•9. Tendency towards malignant hyperthermia；
•10. Allergy to the study drug or other contraindications；
+5 more criteria

Key Dates

Start Date

March 15, 2024

Primary Completion Date

August 1, 2024

Completion Date

December 30, 2024

Last Updated

March 12, 2024

Enrollment

ESTIMATED participants

Conditions

Postoperative Analgesia

Interventions

Paracetamol and Mannitol Injection

DRUG

Parecoxib

DRUG

Contacts

JianHong Xu

CONTACT

86-18867961109 xujh1969@163.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 12, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effect of Paracetamol and Mannitol Injection on Postoperative Analgesia in Patients With Thoracoscopic Lobectomy

Inclusion Criteria

Exclusion Criteria

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