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COMPLETEDNA

Bariatric Surgery and Cardiovascular Responses to Sodium Nitrate

Changes Induced by Bariatric Surgery in Cardiovascular Responses to Dietary Supplementation With Sodium Nitrate

NCT06303830•University of Sao Paulo

Summary

Inorganic nitrite and nitrate can be reduced to NO and NO-related species such as S-nitrosothiols via the nitrate-nitrite-NO pathway. This is due to the reduction of nitrate to nitrite by the action of bacteria in the mouth and the reduction of nitrite to NO depending on the acidic pH on the stomach or by enzymes with nitrite-reductase activity. The acidic environment of the stomach is very important to the formation of NO and S-nitrosothiols and several studies suggest that changes in gastric pH can affect this conversion. In this context, bariatric surgery, by altering the anatomy of the stomach and increasing gastric pH, can affect the nitrate-nitrite-NO pathway and change the antihypertensive and antioxidant effect of sodium nitrate.

Eligibility

Age

18 - 60 years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•For volunteers who underwent bariatric surgery:
•1. Female;
•2. Age over 18 years old and under 60 years old;
•3. Having had bariatric surgery more than 1 and a half years ago;
•4. Present stabilized weight loss;
•For voluntary controls:
•1. Female;
•2. Age over 18 years old and under 60 years old;

Exclusion Criteria

•For volunteers who underwent bariatric surgery and controls:
•1. Having uncontrolled blood pressure (above 160/100 mmHg), even with use regulate up to two antihypertensive agents;
•2. Hypertensive patients must be using a maximum of two antihypertensives;
•3. Have Diabetes Mellitus or other endocrinopathy;
•4. Have kidney or liver failure;
•5. Individuals who smoke.

Locations (1)

Usp - Hospital Das Clínicas Da Faculdade de Medicina de Ribeirão

Ribeirão Preto, São Paulo, Brazil

Key Dates

Start Date

April 16, 2019

Primary Completion Date

December 17, 2020

Completion Date

October 1, 2021

Last Updated

March 12, 2024

Enrollment

ACTUAL participants

Conditions

Hypertension

Interventions

Sodium nitrate

DIETARY_SUPPLEMENT

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 12, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Bariatric Surgery and Cardiovascular Responses to Sodium Nitrate

Inclusion Criteria

Exclusion Criteria

Natural History of Noncirrhotic Portal Hypertension

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