MR Image Synthesis With Low Gadobutrol Dose and AI

Exclusion Criteria

• •1. Considered clinically unstable or has a concomitant/intercurrent condition that would not allow participation in the study.
• •2. Diagnoses of multiple sclerosis or other disease process that is expected to change its enhancement pattern in the time period of the follow-up.
• •3. Brain pathology or abnormalities that are not considered lesions.
• •4. Any contraindication for MRI procedure or gadobutrol administration.
• •5. Has severe cardiovascular disease.
• •6. Is expected or is scheduled to have a change in any treatment or procedure between the two study periods that may alter image comparability.
• •7. Is scheduled or is likely to require a biopsy or any interventional therapeutic procedure from the first study MRI up to 24 hours after the second study MRI.
• •8. Women currently lactating, pregnant, or planning on becoming pregnant during the study.
• •9. Women of childbearing potential with a positive urine pregnancy test within 24 hours before either gadobutrol administration.
• •10. Receipt of any gadolinium-based contrast agent \<72 hours prior to the study MRIs.
• •11. Participants with acute kidney injury.