A Study to Evaluate Efficacy and Safety of HM11260C in Adult Obesity Patients Without Diabetes Mellitus

Exclusion Criteria

• •1. A person whose weight change exceeds 5kg within 3 months prior to screening visit.
• •2. Diabetes mellitus (Type 1, type 2, etc.) or HbA1c ≥ 6.5 %.
• •3. Administration of hypoglycemic agents.
• •4. Administration of medicines inducing weight gain.
• •5. Prader-Willi Syndrome or MC4R deficiency.
• •6. Cushing's Syndrome.
• •7. Administration of medicines for weight management.
• •8. A person who has a history of surgery(including device-based therapy) related to obesity or who has a plan during the clinical trial period.
• •9. Administration of Steroids for the systemic use.
• •10. Clinically significant gastric emptying abnormalities.
• •11. History(including family history) of medullary thyroid carcinoma or multiple endocrine adenomatosis.
• •12. History of acute or chronic pancreatitis.
• •13. A person who has the following clinical laboratory test results :
• •* TSH \< 0.4 mIU/L or TSH \> 6 mIU/L
• •* Calcitonin \> 100 ng/L
• •* Amylase or Lipase \> 3 x UNL
• •14. Severe liver disease (AST or AST \> 3 x UNL or Total bilirubin \> 1.5 x UNL).
• •15. Severe renal disease ( eGFR \< 30mL/min/1.73m 2 ).
• •16. QTc \> 450 ms.
• •17. Answered 'yes' to question 4 or 5 of the suicidal ideation domain in C-SSRS or history of suicide attempt.
• •18. PHQ-9 ≥ 15 or history of depression, anxiety, and other severe Mental illness.
• •19. History of alcohol addiction or drug abuse.
• •20. History of malignant tumors.
• •21. History of severe heart disease or severe neurovascular disease.
• •22. Hypersensitivity to investigational products or multi-drug allergy.
• •23. Positive to pregnancy test, nursing mother, intention on pregnancy.
• •24. Considered by investigator as not appropriate to participate in the clinical study with other reason.