Evaluation of Soy Isoflavones on Skin Ageing Parameters

Evaluation of Oral Soy Isoflavone Concentrates on Skin Ageing Parameters: a Double-blind Randomised Placebo-controlled Trial

NCT06047145•The Archer-Daniels-Midland Company

View on ClinicalTrials.gov

Summary

This double-blind, placebo-controlled, randomised pilot trial aims to assess the effect of oral soy isoflavone consumption on skin ageing parameters in post-menopausal women.

Eligibility

Age

40 - 65 years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•1. Healthy subject.
•2. Sex: female.
•3. Age: from 40 to 65 years (inclusive).
•4. Phototype: I to IV on the Fitzpatrick scale.
•5. Post-menopausal subject, with last menstrual period at least 12 months prior to screening and who is not using hormonal contraception.
•6. Subject having Crow's feet wrinkles from grade 2 to 5 on Bazin's scale.
•7. Subject having under eyes wrinkles.
•8. Subject agreeing not to change her alimentary and cosmetic habits during the study.
•9. Subject, able to understand the study related information and to give a written informed consent.
•10. Subject having given freely and expressly informed consent.
+2 more criteria

Exclusion Criteria

•1. Women with childbearing potential or women on long term hormonal contraception whose childbearing potential is difficult to ascertain.
•2. Subject deprived of her freedom by administrative or legal decision.
•3. Subject under guardianship or unable to provide consent.
•4. Subject in a social or healthcare institution.
•5. Subject suspected to be non-compliant according to the investigator's judgment.
•6. Subject participating in any other clinical study or being in an exclusion period for a previous study.
•7. Subject having crow's feet wrinkles with grades \< 2 or \> 5 on Bazin's scale.
•8. Subject with a tattoo, a scar, moles, too many hairs or anything on the studied zones which might interfere with the evaluation.
•9. Personal or family history of breast, uterine or ovarian cancer as per investigator judgement.
•10. Subject with personal history of cancer.
+25 more criteria

Locations (1)

Eurofins Dermscan Pharmascan

Villeurbanne, France

Key Dates

Start Date

October 27, 2023

Primary Completion Date

February 26, 2024

Completion Date

February 26, 2024

Last Updated

April 10, 2025

Enrollment

ACTUAL participants

Conditions

Skin Ageing

Interventions

soy isoflavones

DIETARY_SUPPLEMENT

Placebo

DIETARY_SUPPLEMENT

Examine Impact of Topical Application of Active Versus Placebo on the Skin Microbiome in Sensitive Skin.

NCT07454525

SkinSkin Microbiome+2 more

View study

NOT_YET_RECRUITINGNA

Clinical Trial to Assess the Efficacy and Safety of a Cosmetic Product in Individuals Showing Signs of Cutaneous Aging.

NCT07343544

SkinSkin Ageing+3 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 10, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions