Blood Pressure and Obstructive Sleep Apnea

The Changes in Blood Pressure in Patients With Obstructive Sleep Apnea Following an Overnight Sleep

NCT06027424•Taipei Veterans General Hospital, Taiwan

Summary

Bidirectional and causal relationship exists between obstructive sleep apnea (OSA) and hypertension in a dose-response manner, independent of confounding variables such as age, smoking, and body mass index. OSA is conventionally diagnosed and graded by apnea-hypopnea index (AHI). The relationship between AHI and changes of blood pressure deserves further investigation.

Detailed Description

Approximately 50% of patients with obstructive sleep apnea (OSA) have hypertension; up to 30% of patients with hypertension have OSA, and the prevalence is even higher in those of resistant hypertension. OSA is conventionally diagnosed and graded by apnea-hypopnea index (AHI). This retrospective study aimed to determine if OSA severity and AHI have effect on blood pressure measurements and the nocturnal changes following an overnight sleep.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•(1). Individuals who underwent full-night polysomnography at Taipei VGH for symptoms related to obstructive sleep apnea, such as snoring and daytime somnolence; (2). Feasibility to measure BP via wrist monitors; (3). Confirmation of wakefulness through electroencephalography.

Exclusion Criteria

•(1). Failure to measure BP via wrist monitors; (2). Age younger than 18 years; (3). Sleep efficiency less than 50%; (4). Central sleep apnea ≥ 50%

Locations (1)

Taipei Veterans General Hospital

Taipei, Taiwan

Key Dates

Start Date

October 26, 2022

Primary Completion Date

February 28, 2023

Completion Date

July 16, 2023

Last Updated

September 7, 2023

Enrollment

2,037

ACTUAL participants

Conditions

The Effects of Obstructive Sleep Apnea on Blood Pressure Measurement

Interventions

OTHER