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Modulating Brain Networks to Reduce Gait Variability in Older Adults at Risk of Falling
Walking is a complex and continuous task that entails repetitive motions of the body. Relatively high gait variability sensitively predicts falls and cognitive decline in older adults. Previous work has identified an unique brain network relationship linked to gait variability and its relevant cognitive function (i.e., sustained attention). This project aims to develop a non-invasive brain stimulation montage designed to modulate the shared brain networks dynamics and to demonstrate its effects on resting state functional connectivity, gait and cognitive performance in older adults at risk for falls.
This is a randomized controlled trial to examine the efficacy of a non-invasive brain stimulation intervention of tDCS to improve unsteady gait in older adults. The investigators will enroll 30 older adults with elevated gait variability. Participants will be randomized into one of two arms: a) 10 sessions of tDCS and b) 5 sessions of sham stimulation followed by 5 sessions of tDCS. Participants will engage in a set of pre-intervention assessments, the brain stimulation intervention - consisting of 10, once-daily, 20-min stimulation sessions over a 2-week period, and a set of post-intervention assessments. This project is expected to demonstrate that tDCS can be used to reduce gait variability in older adults.
Age
65 - No limit years
Sex
ALL
Healthy Volunteers
Yes
Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife
Boston, Massachusetts, United States
Start Date
June 3, 2024
Primary Completion Date
November 20, 2025
Completion Date
November 20, 2025
Last Updated
January 21, 2026
27
ACTUAL participants
Transcranial direct current stimulation (tDCS) (active)
DEVICE
Transcranial direct current stimulation (tDCS) (Sham)
DEVICE
Lead Sponsor
Hebrew SeniorLife
Collaborators
NCT07213804
NCT05281471
Data Source & Attribution
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