Photoprotective Effects of a SPF50+ Sunscreen on Skin Genotoxicity Induced by Repeated Chronic Outdoor Sun Exposure

Exclusion Criteria

• •1. \- Criteria related to the population:
• •* Smoker of more than 10 cigarettes per day containing nicotine, paper and/or electronic cigarette equivalent
• •* Subject having received on study areas artificial UV exposure or excessive, prolonged, and unprotected exposure to natural sunlight within the 4 weeks before the inclusion visit or planning one during the study
• •* Subject having performed excessive and prolonged physical activity (e.g. trail, long distance running, race…) within 7 days before the inclusion visit
• •2. \- Criteria related to the diseases / skin condition:
• •* Subject with a known history of photosensitivity (toxic, allergic)
• •* Subject with a known personal or family history of skin cancer
• •* Subject having hereditary or acquired disorders of hemostasis.
• •3. \- Criteria related to the treatments and/or products:
• •* Physical treatment (radiotherapy, phototherapy, chemical peeling, laser, ...) on the study area within 4 weeks before the inclusion visit or planned during the study.
• •* Systemic or topical treatment applied on the study area (e.g. anti-allergic, anti-inflammatory treatment) within two weeks before the inclusion visit, ongoing or planned during the study and likely to interfere with the study according to the investigator's assessment
• •* Use of anti-aging products (containing retinoids and / or α-hydroxy acids) on the target areas (face and/or forearms) in the 2 weeks before the inclusion visit.
• •* Systemic or topical treatment with photosensitizing or phototoxic potential (NSAIDs, antihistamines, psychotropic drugs, antidepressants, anti-migraine drugs, cyclines, quinolone, antibiotics, beta-blockers, etc.), taken or applied to the study area within the previous weeks, ongoing or planned during the study, and likely to interfere with the study according to the investigator's assessment
• •* Subject taking creatine dietary supplements and/or practicing prolonged fasting