A Study Evaluating The Efficacy and Safety of Neoadjuvant Immunotherapy Combinations in Patients With Surgically Resectable Hepatocellular Carcinoma

Exclusion Criteria

• •Presence of extrahepatic disease or macrovascular invasion
• •Known fibrolamellar HCC, sarcomatoid HCC, mixed cholangiocarcinoma and HCC, or other rare variants of HCC
• •History of hepatic encephalopathy if clinically significant within one year prior to initiation of study treatment
• •Moderate or severe ascites
• •Active co-infection with HBV and HCV
• •Known active co-infection with HBV and hepatitis D viral infection
• •Prior treatment with CD137 agonists or immune checkpoint inhibitors, including anti-CTLA-4, anti-PD-1, and anti-PD-L1 therapeutic antibodies
• •Treatment with investigational therapy within 28 days prior to initiation of study treatment
• •Untreated or incompletely treated esophageal and/or gastric varices with bleeding or that are at high risk for bleeding
• •A prior bleeding event due to esophageal and/or gastric varices within 6 months prior to initiation of study treatment
• •Inadequately controlled hypertension
• •History of hypertensive crisis or hypertensive encephalopathy
• •Significant vascular disease within 6 months prior to initiation of study treatment
• •History of hemoptysis within 1 month prior to initiation of study treatment
• •Evidence of bleeding diathesis or significant coagulopathy
• •Current or recent (\<= 10 days prior to initiation of study treatment) use of full-dose oral or parenteral anticoagulants or thrombolytic agents for therapeutic purposes
• •History of abdominal or tracheoesophageal fistula, GI perforation or intra-abdominal abscesses within 6 months prior to initiation of study treatment
• •History of intestinal obstruction and/or clinical sign or symptoms of GI obstruction
• •Serious, non-healing or dehiscing wound, active ulcer, or untreated bone fracture
• •Grade \>= proteinuria
• •Major surgical procedure, open biopsy, or significant traumatic injury, or abdominal surgery, interventions or traumatic injuries, or anticipation of need of major surgical procedure other than potentially curative liver resection
• •Chronic daily treatment with a non-steroidal anti-inflammatory drug (NSAID)
• •Serious infection requiring oral or IV antibiotics and/or hospitalization
• •Active tuberculosis