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Sodium Channel Mutations in Patient With the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES) | Clinical Trials | Clareo Health

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Sodium Channel Mutations in Patient With the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES)

Sodium Channel Mutations (SCN9A, SCN10A) in the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES)

NCT05877274•Maxima Medical Center

View on ClinicalTrials.gov

Summary

The goal of this observational study is to learn about sodium channel (Nav) mutations in patients with the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES). This study will give more insight into the pathophysiology of ACNES, which is still largely unknown. The primary objective is to determine if there are mutations of Nav1.7 and Nav1.8 in patients with ACNES. Therefore, one blood sample will be drawn, in which the mutations will be analyzed.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•In order to be eligible to participate in this study, a subject must be diagnosed with ACNES and receive treatment at our outpatient clinic. Additionally, subject has to meet one of the following criteria:
•Known to have a first- or second-degree relative with ACNES;
•Have more than one recurrence of ACNES after a pain free period or ACNES at multiple locations in the abdominal wall;
•Persistent pain after posterior neurectomy.

Exclusion Criteria

•Inability to understand Dutch language.
•Known neuromuscular or neurodegenerative disease.

Locations (1)

Maxima Medical Center

Veldhoven, Netherlands

Key Dates

Start Date

October 3, 2023

Primary Completion Date

June 1, 2024

Completion Date

December 1, 2024

Last Updated

October 30, 2023

Enrollment

ESTIMATED participants

Conditions

Anterior Cutaneous Nerve Entrapment SyndromeNerve Entrapment SyndromeChronic Pain Syndrome

Interventions

Sodium channel mutation

OTHER

Contacts

Tom ten Have, MD

CONTACT

0408887461 Tom.ten.Have@mmc.nl

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 30, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Sodium Channel Mutations in Patient With the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES)

Inclusion Criteria

Exclusion Criteria

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