Glutamate Emotion Memory Study

Exclusion Criteria

• •The participant may not enter the study if ANY of the following apply:
• •History of /or current DSM-5 bipolar disorder, schizophrenia or emotionally unstable personality disorder \[co-morbid anxiety disorders (including agoraphobia, generalized anxiety disorder, social anxiety disorder and panic disorder) and Posttraumatic Stress Disorder (PTSD) are allowed\]
• •Participants who fulfil current criteria for other comorbid disorders may still be entered into the study, if, in the opinion of the Investigator, the psychiatric diagnosis will not compromise safety or affect data quality
• •Diagnosis of a major cognitive disorder or evidence of cognitive impairment
• •Clinically significant risk of suicide
• •Participants undergoing or who have undergone electroconvulsive therapy for the treatment of the current episode of depression
• •Substance or alcohol use disorder over the past 6 months
• •Regular alcohol consumption of more than 21 units a week or excessive alcohol consumption up to three days before any of the in-person study visits or inability to abstain from alcohol for more than 3 days
• •Moderate cigarette use (\> 10 cigarettes per day)
• •History of, or current general medical conditions that in the opinion of the Investigator may interfere with the safety of the participant or the scientific integrity of the study
• •Current pregnancy (as determined by urine pregnancy test), breastfeeding, planning a pregnancy, or unwillingness to practice birth control during the course of the study
• •Clinically significant abnormalities of laboratory tests, physical examination, or ECG. A participant with a clinical abnormality or parameters outside the reference range for the population being studied may be included only if the Investigator considers that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures
• •Current or past history of heart rhythm disorders
• •Clinically significant untreated hypertension
• •Any contraindication to MRI including claustrophobia, any trauma or surgery which may have left magnetic material in the body, magnetic implants or pacemakers, and inability to lie still for 1 hour or more
• •Previous participation in a study using the same, or similar, emotional processing tasks in the last three months
• •Previous lifetime use of ketamine or phencyclidine
• •Participant with planned medical treatment within the study period that might interfere with the study procedures
• •Participant who is unlikely to comply with the clinical study protocol or is unsuitable for any other reason, in the opinion of the Investigator.