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The Effectiveness of FiO2 Titration Guided by the Oxygen Reserve Index in Preventing Hyperoxia. | Clinical Trials | Clareo Health

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The Effectiveness of FiO2 Titration Guided by the Oxygen Reserve Index in Preventing Hyperoxia.

Determination of the Incidence of Hyperoxia and the Effectiveness of FiO2 Titration Guided by the Oxygen Reserve Index in Preventing Hyperoxia.

NCT05770583•Tepecik Training and Research Hospital

View on ClinicalTrials.gov

Summary

Oxygen therapy is the most common treatment modality for patients with hypoxemia, but target values for normoxemia are not clearly defined. Therefore, iatrogenic hyperoxemia is a very common situation. Even though there are many side effects reported related to hyperoxemia and hyperoxemia is shown to be related to worse outcome than expected; clinicians still observe hyperoxemia frequently. Oxygen reserve index (ORi™) (Masimo Corp., Irvine, USA) can guide clinicians in detection of hyperoxia. ORi is a parameter which can evaluate partial pressure of oxygen (PaO2) rating from 0 to 1. There are growing evidences in ORi that it might be helpful to reduce hyperoxia in general anesthesia. Continuous ORi monitoring can be used for detecting and preventing hyperoxia. The ability to perform FiO2 titration with ORi may be an appropriate monitoring management to prevent the harmful effects of hyperoxia.In this study, in patients who underwent major abdominal surgery; It was aimed to investigate the effectiveness of ORi-guided FiO2 titration in preventing hyperoxia.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Patients older than 18,
•2. Patients scheduled for major abdominal surgery that are expected to last longer than 2 hours
•3. Patients that have invasive arterial monitorization
•4. American Society of Anesthesiologists physical class I, II or III.

Exclusion Criteria

•1. Patients younger than 18
•2. Patients that need to be treated with high doses of vasopressors,
•3. Patients having peripheric hypoperfusion,
•4. Hemodynamically unstable patients,
•5. Patients with hemoglobinopathy,
•6. Pregnancy,
•7. Morbid obesity (bmi\>40 kg/m2),
•8. Patients with arrythmia that can result in hemodynamic instability, patients with acute coronary syndrome
•9. Acute respiratory failure or ARDS.

Locations (1)

Tepecik Research and Training Hospital

Izmir, Konak, Turkey (Türkiye)

Key Dates

Start Date

September 1, 2020

Primary Completion Date

December 1, 2022

Completion Date

March 5, 2023

Last Updated

March 16, 2023

Enrollment

ACTUAL participants

Conditions

HyperoxiaComplication

Interventions

Titration of fraction of inspired oxygen (FiO2) guided by ORI and oxygen saturation

PROCEDURE

SpO2 (oxygen saturation)

PROCEDURE

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 16, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Effectiveness of FiO2 Titration Guided by the Oxygen Reserve Index in Preventing Hyperoxia.

Inclusion Criteria

Exclusion Criteria

OSA Risk Level in Dental Patients and Correlation With Complications After General Anesthesia

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