Screening Algorithm for Early Detection of Occult Cardiac Amyloidosis

Inclusion Criteria

• •Fulfillment of following four criteria: 1) Severe aortic stenosis. 2) Age \> 65 years for male and \>70 years for female. 3) Increased left ventricular wall thickness ≥14 mm. 4) Blood pressure ≤ 140/90 mmHg and at least 1 major or ≥ 2 minor criteria.
• •Major criteria:
• •1. Carpal tunnel syndrom
• •2. Non-traumatic rupture of the biceps tendon
• •3. NT-proBNP \> 1000 pg/ml
• •4. hs Troponin value above the 99th percentile without dynamic changes (≤ 20%)
• •Minor criteria:
• •1. Diastolic dysfunction (at least grade 2, E' \< 10 cm/s)
• •2. Sinus bradycardia/AV block/pacemaker
• •3. Atrial fibrillation