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Effect of Short Term Time Restricted Eating on Innate Immunity in Patients With Coronary Artery Disease
The goal of this cross over study is to investigate the effect of short term time restricted eating (TRE) on the innate immune system in patients with a history of myocardial infarction.
In the recent years, research has shown the prominent role of low grade systemic inflammation in cardiovascular disease (CVD) and the crucial role myeloid cells, mainly monocytes and macrophages, play in atherogenesis. Time restricted eating (TRE), i.e. eating the normal amount of calories within a limited time period per day, has a beneficial effect on multiple factors involved in the development of CVD, such as blood pressure, heart rate, lipid and blood glucose levels, and insulin sensitivity. TRE also reduces markers of systemic inflammation and reduces the number of circulating monocytes. It is now hypothesized that TRE reduces the pro-inflammatory monocyte phenotype of patients with a history of myocardial infarction. Therefore, the investigators will perform a exploratory prospective randomised open label blinded endpoint cross-over study to investigate the effect of short term TRE on the innate immune system in patients with a history of myocardial infarction.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Radboud university medical center
Nijmegen, Gelderland, Netherlands
Start Date
November 17, 2022
Primary Completion Date
January 25, 2024
Completion Date
January 25, 2024
Last Updated
March 27, 2024
23
ACTUAL participants
Time restricted eating (TRE)
BEHAVIORAL
Regular diet
BEHAVIORAL
Lead Sponsor
Radboud University Medical Center
Collaborators
NCT05198791
NCT06744322
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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View ClinicalTrials.gov Terms and ConditionsNCT06813911