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Dried Purple Laver (Nori) as a Food Source of Vitamin B12 in Vegetarians | Clinical Trials | Clareo Health

COMPLETEDNA

Dried Purple Laver (Nori) as a Food Source of Vitamin B12 in Vegetarians

The Bioavailability of Vitamin B12 From Nori in Vegetarians: a Dose Response Study

NCT05614960•Fu Jen Catholic University

View on ClinicalTrials.gov

Summary

This is an intervention study aiming to understand the bioavailability of vitamin B12 from nori for vegetarians.

Detailed Description

Thirty vegetarian participants will be randomly assigned to one of three intervention arms: (1) 5g of nori (4 sheets, containing 2.4μg vitamin B12), (2) 8g nori (7 sheets, containing 4μg vitamin B12), (3) control group (no nori). At baseline and end of 4 weeks, participants will be measured on serum vitamin B12, methylmalonic acid, holotranscobalamin, homocysteine and folate.

Eligibility

Age

20 - 60 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Vegetarians (including vegan, ovo-vegetarian, lacto-vegetarian, lacto-ovo vegetarian)
•Duration of the vegetarian diet: at least 1 year
•Aged 20-60 years old
•Have not taken vitamin B12 or folate supplement within 1 year
•Willing to adhere to study intervention and be tested for vitamin B12 related biomarkers.
•Familiar with LINE application on smartphone

Exclusion Criteria

•Any disease or surgery that affects the vitamin B12 status (Pernicious anemia, Gastrointestinal disease and surgery, Pancreatic diseases, Chronic kidney disease)
•Hyperthyroidism
•Previous adverse reaction to nori
•Have taken antacid or metformin in the past 1 week
•Alcoholic and not willing to abstinence from alcoholic beverages

Locations (1)

Department of Nutritional Science, Fu-Jen Catholic University

New Taipei City, Taiwan

Key Dates

Start Date

November 7, 2022

Primary Completion Date

March 31, 2023

Completion Date

March 31, 2023

Last Updated

June 1, 2023

Enrollment

ACTUAL participants

Conditions

Vitamin B 12 Deficiency

Interventions

Dried purple laver (Nori)

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 1, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Dried Purple Laver (Nori) as a Food Source of Vitamin B12 in Vegetarians

Inclusion Criteria

Exclusion Criteria

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