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Impact of Time Restricted Feeding on Daily Protein Requirements | Clinical Trials | Clareo Health

COMPLETEDNA

Impact of Time Restricted Feeding on Daily Protein Requirements

NCT05610644•University of Arkansas

Summary

Detailed Description

The investigators aim to assess 24-hour protein kinetics at two different levels of protein intake: 0.8 (RDA) and 1.6g/kg/day (2RDA) during a normal dietary (TRAD) and a time restricted feeding (TRF) pattern in older adults. Individuals in the TRF pattern will only consume food during a 6-hour eating period and fast for the remaining 18 hours. Individuals in the TRAD pattern will consume isocaloric and isonitrogenous (RDA or 2RDA) diet but consume an all-beef-breakfast. Participants will consume oral stable isotopes to measure muscle protein synthesis (MPS), whole-body muscle protein breakdown (MPB), and whole-body protein balance (WBPB). Appropriate muscle, blood samples, and urine will be collected throughout a 24-hour metabolic trial following a 2-day controlled diet.

Eligibility

Age

50 - 75 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Men and women ages 50-75 years.
•2. BMI 20-30 kg/m2 inclusive.
•3. Capable of providing informed consent.
•4. COVID-19 negative and/or asymptomatic

Exclusion Criteria

•1. Subject who does not/will not eat animal protein sources.
•2. Body mass index \<20 or \>30.
•3. Hemoglobin \<10g/dL at screening.
•4. Platelets \<150,000/uL at screening.
•5. History of diabetes.
•6. History of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment.
•7. History of gastrointestinal bypass/reduction surgery.
•8. History of a chronic inflammatory disease (e.g. what?)
•9. Currently receiving androgen (e.g., testosterone) or anabolic (e.g., GH, IGF-I) therapy.
•10. Currently using prescription blood thinning medications.
+5 more criteria

Locations (1)

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Key Dates

Start Date

March 29, 2023

Primary Completion Date

October 3, 2024

Completion Date

October 3, 2024

Last Updated

December 20, 2024

Enrollment

ACTUAL participants

Conditions

Nutrition Disorders in Old Age

Interventions

isocaloric, isonitrogenous meals

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COMPLETEDNA

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 20, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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