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Intraluminal Peppermint Oil and Adenoma Detection Rate in Screening Colonoscopy | Clinical Trials | Clareo Health

COMPLETEDNA

Intraluminal Peppermint Oil and Adenoma Detection Rate in Screening Colonoscopy

Intraluminal Peppermint Oil Can Increase Adenoma Detection Rate in Colon Cancer Screening Colonoscopy: A Double- Blinded Randomized Controlled Trial

NCT05559814•Mahidol University

View on ClinicalTrials.gov

Summary

This is a prospective randomized placebo-controlled trial to evaluate the efficacy of peppermint oil spraying into the colonic lumen through the scope channel during screening colonoscopy. The primary outcome is to compare the colonic peristalsis between peppermint oil and placebo. The secondary outcomes compare the procedural time, polyp detection rate, adenoma detection rate, and adverse events.

Eligibility

Age

18 - 100 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•\- Participants with age \> 18 years who attended for colorectal cancer screening colonoscopy.

Exclusion Criteria

•Participants who had been colectomy
•Participants who diagnosed of inflammatory bowel disease or polyposis syndrome.
•Participants who had been took anti-spasmosic drugs prior to colonoscopy within 24 hours (Anticholibergic/Antimuscarinic : Hyoscine(Buscopan®), Dicyclomine(Berclomine®) or Smooth muscle relaxant : Mebeverine(Duspatin®,Colofac®), Pinaverium bromide(Dicetel®), Alverine(Meteospasmyl®), Peppermint oil(Colpermin®))
•Participants with Prothrombin time \> 3 second ULN, INR \> 1.5 or Platelet \< 50,000.
•Pregnancy or breast feeding
•Participants who cannot consent.
•Participants who had history of peppermint oil allergy.

Locations (1)

Faculty of internal medicine siriraj hospital, Mahidol university

Bangkok Noi, Bangkok, Thailand

Key Dates

Start Date

March 1, 2021

Primary Completion Date

May 31, 2022

Completion Date

June 30, 2022

Last Updated

April 5, 2023

Enrollment

404

ACTUAL participants

Conditions

Colonic Polyp

Interventions

Intraluminal peppermint oil

DRUG

Placebo

DRUG

Training Physicians to Differentiate the Paris Classification Using Artificial Colon Polyp Images

NCT06550908

Colonic PolypColon Adenoma

View study

RECRUITINGNA

Prospective, Open-label, Non-significant Risk, Multicenter Study Comparing the Polyp Detection of the Study Device to That of the Colonoscopy Reference

NCT07089615

Colonic Polyps

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 5, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Intraluminal Peppermint Oil and Adenoma Detection Rate in Screening Colonoscopy

Inclusion Criteria

Exclusion Criteria

Training Physicians to Differentiate the Paris Classification Using Artificial Colon Polyp Images

Prospective, Open-label, Non-significant Risk, Multicenter Study Comparing the Polyp Detection of the Study Device to That of the Colonoscopy Reference

A Clinical Study on Endoscopic and Histopathological Outcomes of Screening and Surveillance Colonoscopies

Effective Withdrawal Time and Adenoma Detection Rate

Computer Aided Polyp Detection (C3PO) Trial

Comparison Rectal Endoscopic Submucosal Dissection to Endoscopic Mucosal Resection