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COMPLETEDNA

Hemodynamic in Postreperfusion Period and Functional Recovery in Acute Ischemic Stroke Patients

The Influence of Different Hemodynamic Parameters in First 24 Hours After Intravenous Thrombolysis on Acute Ischemic Stroke Outcomes: a Randomised Clinical Trial

NCT05517109•Northern State Medical University

View on ClinicalTrials.gov

Summary

The investigators are suggtesting that lower goals of systolic blood pressure after intravenous thrombolysis may reduce the risk of hemorrhagic complications and improve functional outcomes after acute ischemic stroke.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Inclusion сriteria:
•ischemic stroke diagnosis
•performed intravenous thrombolysis (including "wake up stroke")
•systolic blood pressure \>140 mmHg
•informed consent or council of physician agreement

Exclusion Criteria

•absence of informed consent or council of physician agreement
•pregnancy
•patients participainting in other clinical trial in the last 90 days
•any absolute contraindications to intravenous thrombolysis
•Сompletion criteria:
•failure to achieve hemodynamic goal for 20 minutes before the start of intravenous thrombolysis
•failure to achieve hemodynamic goal for 60 minutes in first 24 hours after intravenous thrombolysis
•relative arterial hypotension (SBP \<100 mmHg for 60 minutes in first 24 hours after intravenous thrombolysis)
•unfavorable effect development (e.g. seizures, angioedema)
•informed consent is retracted

Locations (1)

City Hospital # 1 n.a. E.E. Volosevich

Arkhangelsk, Russia

Key Dates

Start Date

March 12, 2022

Primary Completion Date

April 30, 2024

Completion Date

August 31, 2024

Last Updated

October 30, 2024

Enrollment

ACTUAL participants

Conditions

Acute Ischemic StrokeIntracranial Hemorrhage

Interventions

Hemodynamic goal including lower goal of systolic blood pressure

OTHER

Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 Hours

NCT07253181

Acute Ischemic StrokeLarge Vessel Occlusion+1 more

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RECRUITINGPHASE2/PHASE3

Optimizing Reperfusion to Improve Outcomes and Neurologic Function

NCT06990867

Acute Ischemic Stroke

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 30, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Hemodynamic in Postreperfusion Period and Functional Recovery in Acute Ischemic Stroke Patients

Inclusion Criteria

Exclusion Criteria

Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 Hours

Optimizing Reperfusion to Improve Outcomes and Neurologic Function

Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke

Brain, Blood And Clot or Tissue Registry And Collaboration

A Study of the Safety, Tolerability and Preliminary Efficacy of B2065 in Patients With Acute Ischemic Stroke.

Radiohistological Correlation of Thrombohemorrhagic Remodeling in the Acute Phase of Ischemic Stroke Managed by Decompressive Hemicraniectomy