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Modulation of Post-operative Opioid Consumption and Pain by Intraoperative Methadone for Cancer Related Spinal Surgery - An Investigator Initiated Trial (IIT), Cluster Randomization Trial
The researchers are doing this study to find out whether giving methadone during spinal surgery helps manage pain in the first 72 hours after surgery better than other standard pain medications. Participants' pain will be measured by how much pain is reported after surgery, and how much additional pain medication is needed to lower pain levels. The researchers will look at whether giving methadone during surgery reduces the need for other pain medications after surgery. In addition, the team will compare the effects of the two standard treatments- one with methadone and one without methadone to to evaluate which one works best.
Age
18 - 75 years
Sex
ALL
Healthy Volunteers
No
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States
Start Date
June 6, 2022
Primary Completion Date
June 1, 2027
Completion Date
June 1, 2027
Last Updated
January 27, 2026
17
ACTUAL participants
Methadone
DRUG
Lead Sponsor
Memorial Sloan Kettering Cancer Center
NCT06857760
NCT03501810
NCT00491608
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