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Establishment of a Quantified Imaging Method for Evaluating Tumor Response Grade in Rectal Cancer Patient With Neoadjuvant Therapy: a Multi-center Study
This study proposeto integrate a variety of imaging quantitative indicators to establish a new MRI-based tumor response regression(mrTRG) classification method. The accuracy of the established mrTRG classification method according pathology TRG(pTRG) will be tested. The ability of the established mrTRG classification method to predict prognosis will also be tested.
The study included two part: one is a retrospective single-center cohort for analyzing quantitative MRI factors associated with pTRG, from which a new MRI-based tumor response regression(mrTRG) classification method will be established. The other is a prospective multi-center cohort for testing the accuracy of the established mrTRG classification according to pTRG; and also for validating the established mrTRG classification associated with survival.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Chinese PLA General Hospital
Beijing, Beijing Municipality, China
Beijing Cancer Hospital
Beijing, Beijing Municipality, China
Peking University Shougang Hospital
Beijing, Beijing Municipality, China
Start Date
May 18, 2020
Primary Completion Date
April 30, 2023
Completion Date
December 31, 2025
Last Updated
June 22, 2023
385
ACTUAL participants
pelvic MRI for establishing new mrTRG method
DIAGNOSTIC_TEST
Lead Sponsor
Peking University Cancer Hospital & Institute
Collaborators
NCT04929028
NCT04704661
Data Source & Attribution
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