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Effect of Intrapulmonary Percussion Ventilation on Deposition of Inhaled Aerosols in Idiopathic Pulmonary Fibrosis | Clinical Trials | Clareo Health

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Effect of Intrapulmonary Percussion Ventilation on Deposition of Inhaled Aerosols in Idiopathic Pulmonary Fibrosis

NCT05366387•University Hospital, Tours

View on ClinicalTrials.gov

Summary

This protocol aims to evaluate the feasibility and benefit of Intrapulmonary Percussive Ventilation (IPV) to improve deposition of inhaled radiolabelled aerosols in fibrotic lung regions of patients with Idiopathic Pulmonary Fibrosis (IPF). Phase 1 of the protocol aims to identify the highest IPV pressure that is tolerated by individual patients. Secondary endpoints explore safety of IPV in IPF patients. Phase 2 of the protocol is a crossover randomized trial where patients will inhale 99mTc-labelled DiethyleneTriamine PentaAcetate (DTPA) aerosols with or without IPV. Aerosol deposition in HRCT-defined fibrotic regions of interest (ROI) is described by Single Photon Emission Computed Tomography (SPECT).

Eligibility

Age

50 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Diagnosis of IPF according to 2018 ATS/ERS/JRS/ALAT guidelines
•Affiliation to health insurance
•Signed informed consent

Exclusion Criteria

•Other chronic lung disease
•Airflow obstruction (FEV1/FVC\<0.7)
•History of congestive heart failure
•History of IPF exacerbation
•History of lung cancer
•Chronic cough precluding aerosol delivery and radioprotection
•Claustrophobia
•24h/24 oxygen therapy
•Any acute lung disease
•Any potentially transmissible lung infection
+6 more criteria

Locations (1)

Pulmonology Department, University Hospital, Tours

Tours, France

Key Dates

Start Date

November 23, 2022

Primary Completion Date

February 12, 2025

Completion Date

February 12, 2025

Last Updated

December 1, 2025

Enrollment

ACTUAL participants

Conditions

Idiopathic Pulmonary Fibrosis

Interventions

intrapulmonary percussive ventilation

DEVICE

delivery of 99mTc-DTPA aerosol

RADIATION

A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

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Idiopathic Pulmonary FibrosisProgressive Pulmonary Fibrosis

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RECRUITINGPHASE3

Intravenous Immunoglobulin for the Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 1, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effect of Intrapulmonary Percussion Ventilation on Deposition of Inhaled Aerosols in Idiopathic Pulmonary Fibrosis

Inclusion Criteria

Exclusion Criteria

A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

Intravenous Immunoglobulin for the Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis

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